The Glymphatic System 

Meets

The Cranial Rhythmic Impulse (CRI)

www.neurosciencenews.com

What is the
Glymphatic System ?

“Much remains to be studied,
but we propose that the glymphatic/lymphatic system
acts as a cornerstone in the architecture

 of the brain and body signaling.”

This observation may have profound impact
on our understanding of
inflammatory and neurodegenerative disease.

“…to answer fundamental questions about this system… 
we will need fresh perspectives, new techniques,
and collaborations across disciplines,

not only within neurobiology and sleep physiology,
but also across immunology, lymphatic biology,
fluid dynamics and more.”

The first half of the 20th century saw the birth
 and the teaching of the Cranial Concept
 within the Osteopathic community. 

The concept and its practice spread worldwide
 in the second half of the 20th century.

Are the unidentified ‘pulsations’ and ‘oscillations’
observed in current glymphatic research going
to confirm William Garner Sutherland’s 1899
‘aha‘ observation in medical school?

What will the first half of the 21st century reveal?
Is Cranial Osteopathy the fresh perspective?
Will there be collaboration across disciplines?

Current Biology  |  25 October, 2021 
 Lauren M. Hablitz, Maiken Nedergaard

Center for Translational Neuromedicine, University of Rochester Medical Center,
Rochester, NY 24642, USA

Center for Translational Neuromedicine,
Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen Denmark

….the brain uses a network termed
 the glymphatic system
 to support a constant influx of cerebrospinal fluid (CSF)
that drives the export of metabolic waste.

…to answer fundamental questions about this system… 
we will need fresh perspectives, new techniques,
and collaborations across disciplines,
not only within neurobiology and sleep physiology, but also
across immunology, lymphatic biology, fluid dynamics and more.”

The Glymphatic System

Cerebrospinal Fluid Circulation

The Glymphatic System

Recent scientific publications illustrate the current interest in this newly discovered
Glymphatic System.

The Sleeping Brain:
Harnessing the Power
of the Glymphatic System
through Lifestyle Choices

Brain Sciences  | Published 17 November 2020
Department of Anatomy and Neurosciences,  Amsterdam

“…the glymphatic system,
which stands for glial-dependent lymphatic transport,
been categorized as a macroscopic waste clearance system.

Due to the similarities in function,
the glymphatic system has been described as
the central nervous system’s analogue
to the lymphatic system [1,2].”

 

The Sleeping Brain
“Since this is a relatively new discovery,
the amount of scientific literature surrounding
the glymphatic system is rapidly increasing,
and therefore its definition is continuously being renewed.”

“This has caused controversy surrounding both the directionality
 and the anatomical space in which this system resides.

Impaired glymphatic clearance has been linked to
neurodegenerative diseases [1].”

“Sleep is a primary driver of glymphatic clearance……
The physical forces propelling CSF in glymphatic clearance are intracranial pulsations.”

“Paradoxically, the N3 sleep stage which has the highest levels of CSF influx and amyloid-beta removal
also has the lowest rates of arterial pulsations [13], 
suggesting that other factors are at play.

Only recently,
 lower-frequency intracranial pressure oscillations  
produced by respiration
 were shown to complement cardiac pulsations,
which could alternatively drive clearance.”

 

The Glymphatic System:
A Novel Component of
Fundamental Neurobiology

The Journal of Neuroscience   |  Published 15 September 2021

Center for Translational Neuromedicine,
University of Rochester and
Center for Basic and Translations Neuroscience,
University of Copenhagen

“Much remains to be studied,
but we propose that the glymphatic/lymphatic system acts as a cornerstone in the architecture
 of the brain and body signaling.”

 


The Glymphatic System

“Since its elucidation in 2012,
the glymphatic system has provoked controversy,
primarily because of a lack of data
and adequate tools to characterize noninvasively
 a low-pressure fluid transport system
 residing in an electrically active organ
  encased within the rigid walls of the skull.

 

Specifically, future work should focus on
how to manipulate the availability of CSF
to supply the glymphatic system,
and to elucidate the underlying
physiological mechanisms
that redistribute CSF
between the brain and the body.

 

Magnetic Resonance Imaging
Provides Evidence of Glymphatic Drainage from Human Brain
 to Cervical Lymph Nodes

Nature Scientific Reports  | 18 May 2018
Per Kristian EideSvein Are Sirirud Vatnehol
Kyrre Eeg Emblem & Geir Ringstad 

“Peak CSF (cerebrospinal fluid)
tracer uptake in the
glymphatic system and
cervical lymph nodes
coincides in time.”

Eide, P.K., Vatnehol, S.A.S., Emblem, K.E. et al. Magnetic resonance imaging provides evidence of glymphatic drainage
 from human brain to cervical lymph nodes. 
Sci Rep 8, 7194 (2018). https://doi.org/10.1038/s41598-018-25666-4

Non-invasive MR
Imaging of Human Brain Lymphatic Networks
with Connections to Cervical Lymph Nodes

“3D T2-Fluid Attenuated Inversion Recovery [FLAIR]
magnetic resonance imaging relies on internal signals
 of protein rich lymphatic fluid rather than contrast media
and is used in the present study to visualize
 the major human dural lymphatic structures. 

Moreover we detect direct connections
between lymphatic fluid channels
along the cranial nerves and vascular structures
and the cervical lymph nodes..”

The Glymphatic System
More Scientific Research

The Cranial Rhythmic Impulse (CRI)

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